Event-related desynchronization, as a proxy for mirror neuron activity, has been used as a neurophysiological marker for motor execution after mirror visual feedback. Using EEG, this study investigated ERD upon the immediate effects of single-session MVF in unimanual arm movements compared with the ERD effects occurring without a mirror, in two groups: stroke patients with left hemiplegia and their healthy counterparts. During EEG recordings, each group performed one session of mirror therapy training in three task conditions: with a mirror, with (...) no mirror, and with a covered mirror. An asymmetry index was calculated from the subtraction of the event-related spectrum perturbations between the C3 and C4 electrodes located over the sensorimotor cortices contralateral and ipsilateral to the moved arm. Results of the effect of task versus group in contralateral and ipsilateral motor areas showed that there was a significant effect of task condition at the contralateral motor area in the high beta band at C3. High beta ERD showed that the suppression was greater over the contralateral hemisphere than it was over the ipsilateral hemisphere in both study groups. The magnitude of low beta ERD in patients with stroke was more suppressed in contralesional C3 under the no mirror compared to that of the covered mirror and similarly more suppressed in ipsilesional C4 ERD under the no mirror compared to that of the mirror condition. The correlation analysis revealed that the magnitude of ERSP power correlated significantly with arm severity in the low and high beta bands in patients with stroke, and a higher asymmetry index in the low beta band was associated with higher arm functioning under the no-mirror condition. There was a shift in sensorimotor ERD toward the contralateral hemisphere as induced by MVF accompanying unimanual movement in both stroke patients and healthy controls. The use of ERD in the low beta band as a neurophysiological marker to indicate the relationships between the amount of MVF-induced ERD attenuation and motor severity, and the outcome indicator for improving stroke patients’ neuroplasticity in clinical trials using MVF are warranted to be explored in the future. (shrink)

© 2015, Springer-Verlag Berlin Heidelberg.Genetic studies have identified single nucleotide polymorphisms associated with the risk of prostate cancer. It remains unclear whether such genetic variants are associated with disease aggressiveness. The NCI-SPORE Genetics Working Group retrospectively collected clinicopathologic information and genotype data for 36 SNPs which at the time had been validated to be associated with PC risk from 25,674 cases with PC. Cases were grouped according to race, Gleason score and aggressiveness. Statistical analyses were used to compare the frequency (...) of the SNPs between different disease cohorts. After adjusting for multiple testing, only PC-risk SNP rs2735839 was significantly and inversely associated with aggressive and high-grade disease in European men. Similar associations with aggressive and high-grade disease were documented in African-American subjects. The G allele of rs2735839 was associated with disease aggressiveness even at low PSA levels in both European and African-American men. Our results provide further support that a PC-risk SNP rs2735839 near the KLK3 gene on chromosome 19q13 may be associated with aggressive and high-grade PC. Future prospectively designed, case-case GWAS are needed to identify additional SNPs associated with PC aggressiveness. (shrink)

Study of rationalism in Urdu literature.

On Sikh ethics; includes brief biographies of Sikh religious leaders.

"There are no paradoxes in mathematics," says Kurt Gödel. Moreover, Gödel seems to be right on this count. That is, there are no paradoxes, in the strict sense of the word, internal to the known and available body of mathematical knowledge. But while there are no paradoxes in mathematics, there certainly is an embarrassing bag of difficulties when we come to the application of mathematical concepts to the physical world. Of these, perhaps the most unruly offenders of all are the (...) problems proposed about 2500 years ago by Zeno and which, in modern idiom, have to do with the proper mathematical treatment of phenomena involving change and motion, and the physical meaning—if any—which may be assigned to convergent infinite series. At each stage in the growth of mathematical knowledge since their formulation Zeno's paradoxes have been the subject of some alleged resolution. Now Grünbaum contributes to this tradition, and it must be said that he makes a strong case. The weapons in the intellectual arsenal which Grünbaum brings to bear upon Zeno include such sophisticated devices as measure theory, but the weak link in the argument is in the first chapter where the author presents his somewhat psychologistic theory of temporal becoming. Grünbaum has a great many interesting things to say in later chapters about infinite processes, quantum mechanics, and Hilary Putnam. This is a first-rate contribution to the philosophy of physics.—H. P. K. (shrink)

Stoicism is now widely recognised as one of the most important philosophical schools of ancient Greece and Rome. But how did it influence Western thought after Greek and Roman antiquity? The question is a difficult one to answer because the most important Stoic texts have been lost since the end of the classical period, though not before early Christian thinkers had borrowed their ideas and applied them to discussions ranging from dialectic to moral theology. Later philosophers became familiar with Stoic (...) teachings only indirectly, often without knowing that an idea came from the Stoics. The contributors recruited for this volume, first published in 2004, include some of the leading international scholars of Stoicism as well as experts in later periods of philosophy. They trace the impact of Stoicism and Stoic ideas from late antiquity through the medieval and modern periods. (shrink)

Context: Many recent research areas such as human cognition and quantum physics call the observer-independence of traditional science into question. Also, there is a growing need for self-reflexivity in science, i.e., a science that reflects on its own outcomes and products. Problem: We introduce the concept of second-order science that is based on the operation of re-entry. Our goal is to provide an overview of this largely unexplored science domain and of potential approaches in second-order fields. Method: We provide the (...) necessary conceptual groundwork for explorations in second-order science, in which we discuss the differences between first- and second-order science and where we present a roadmap for second-order science. The article operates mainly with conceptual differentiations such as the separation between three seemingly identical concepts such as Science II, Science 2.0 and second-order science. Results: Compared with first-order science, the potential of second-order science lies in 1. higher levels of novelty and innovations, 2. higher levels of robustness and 3. wider integration as well as higher generality. As first-order science advances, second-order science, with re-entry as its basic operation, provides three vital functions for first-order science, namely a rich source of novelty and innovation, the necessary quality control and greater integration and generality. Implications: Second-order science should be viewed as a major expansion of traditional scientific fields and as a scientific breakthrough towards a new wave of innovative research. Constructivist content: Second-order science has strong ties with radical constructivism, which can be qualified as the most important root/origin of second-order science. Moreover, it will be argued that a new form of cybernetics is needed to cope with the new problems and challenges of second-order science. (shrink)

DaB fUr die Entwicklung der Phanomenologie Husserls nicht zuletzt auch,wissenschaftstheoretische' Motive ausschlaggebend waren, ist hinreichend bekannt. Umso mehr verwundert es, daB die Husserl-Rezeption sich diese Motive nur selten zueigen gemacht hat. Zwar sind in einer Reihe von Einzel­ wissenschaften, wie in der Literaturwissenschaft, der Sozialwissenschaft und besonders auch der Psychologie, phanomenologische Motive wirksam gewor­ den. Versuche einer ausdriicklichen wissenschaftskritischen Anwendung der Husserlschen Philosophie auf einzelwissenschaftliehe Theorien jedoch, wie sie z.B. Alfred Schiitz in seinem friihen Werk zur phanomenologischen Grundlegung der "verstehenden (...) Soziologie"l ansatzweise unternommen hat, sind rar. Freilich ging auch Husserl hier nieht eben mit gutem Beispiel voran. Auch er selbst hat seine wissenschaftstheoretische Programmatik nirgends einer ernsthaften Bewahrungsprobe unterzogen. Die vorliegende Untersuchung will diese Frage einer wissenschaftstheore­ tischen Anwendbarkeit der transzendentalen Phiinomenologie paradigmatisch im Hinblick auf die Problemstellungen der Geschiehtswissenschaft iiberprii­ fen. Was also kann die Phanomenologie fUr die Historik leisten? DaB sieh fiir eine solche Absieht gerade die geschichtstheoretischen Perspektiven in Hus­ serls Werk anbieten, hat vor allem zwei Griinde. (shrink)

Context: The journal Constructivist Foundations celebrates ten years of publishing articles on constructivist approaches, in particular radical constructivism. Problem: In order to preserve the sustainability of radical constructivism and regain its appeal to new generations of researchers, we set up a new course of action for and with the radical constructivist community to study its innovative potential. This new avenue is “second-order science.” Method: We specify two motivations of second-order science, i.e., the inclusion of the observer, and self-reflexivity that allows (...) second-order science to operate on the products of normal or first-order science. Also, we present a short overview of the contributions that we have collected for this inaugural issue on second-order science. Results: These six initial contributions demonstrate the potential of the new set of approaches to second-order science across several disciplines. Implications: Second-order science is believed to be a cogent concept in the evolution of science, leading to a new wave of innovations, novel experiments and a much closer relationship with current research in the cognitive neurosciences in particular, and with evolutionary and complexity theories in general. (shrink)

The aim of this dissertation is to present a systematic account of F. H. Bradley's philosophy in so far as it is relevant to an understanding of his conception of the nature and criterion of truth. I argue that, for Bradley, the nature of truth is the identity of thought with reality given in immediate experience. There is no absolute separation between thought and its object. Bradley therefore rejects both the correspondence theory and epistemological realism. Thought is not just a (...) mirror which reflects an independently existing reality. ;Concerning the criterion of truth, I argue that his criterion for our ordinary and scientific beliefs is practice, and the criterion for philosophical positions is a kind of coherence based on the doctrine of relative truth. For Bradley, some positions are truer than others, and the best philosophy is a comprehensive system which contains the truth of all different positions. ;Bradley does not accept the coherence theory of justification as it is understood today, since it is based on the standard account of negation and the doctrine of absolute truth. Bradley has a different approach to negation and inconsistency, according to which there are no absolutely inconsistent beliefs. Further, he insists that truth is not absolute but "relative," a matter of degree. All philosophical positions contain some truth, and none is completely false. The truth in philosophy is a position which accounts for the whole of reality and includes all apparently inconsistent positions within it. ;I explain Bradley's place in the history of philosophy and show his connections with the British empiricist tradition. I believe one of Bradley's central concerns is to explain the nature and criterion of truth in philosophy within the constraints of empiricism. I also contrast Bradley's positions on important issues with those of philosophers in the Anglo-American analytic tradition, such as Russell, Moore, Ayer, Tarski, Quine, Churchland, Lehrer and Campbell. I argue that most recent commentators on Bradley overlook the importance of understanding his philosophy as a system constructed according to the doctrine of relative truth. (shrink)

The concept of experience has been central to European philosophy since Descartes. He was the first to use experience to distinguish between two kinds of substance, mental and material, on the basis of the fact that one kind of substance is extended but does not think, while the other kind thinks, doubts, wills, imagines and feels, but is not extended. Other philosophers, such as Hobbes, Locke and Hume, made the concept of experience the basis of their analysis of knowledge. These (...) ideas have become part of common sense, and provide the background for a range of philosophical problems from Descartes’ time to the present. While the concept of experience is important for philosophy, philosophers do not all have the same understanding of the nature of experience. (shrink)

Translation and interpretation of selected Hadith on Islamic ethics and coduct.

Context: Although second-order cybernetics was proposed as a new way of cybernetic investigations around 1970, its general status and its modus operandi are still far from obvious. Problem: We want to provide a new perspective on the scope and the currently available potential of second-order cybernetics within today’s science landscapes. Method: We invited a group of scholars who have produced foundational work on second-order cybernetics in recent years, and organized an open call for new approaches to second-order cybernetics. The accepted (...) contributions are discussed and mapped. We also investigate the relations between second-order cybernetics and second-order science. Results: We present a coherent outlook on the scope of second-order cybernetics today, identify a general methodology of science and show that second-order cybernetics can be used in a large number of disciplines that go well beyond purely scientific domains. These results are based on a new epistemic mode “from within,” which can be traced back directly to von Foerster. We also arrived at the conclusion that from its early years onwards second-order cybernetics was developed in two different ways, so that second-order cybernetics and second-order science operate in different domains. Implications: Both the coherent perspective of the scope of second-order cybernetics with a new five-part agenda and the outline for a general methodology of science based on a new epistemic mode that was created within and for second-order cybernetics demonstrate the growing importance of reflexivity in science, which, so far, has not been widely recognized. (shrink)

Islamic ethics in the light of Qurʼanic teaching and Hadith; Customs and practices.

In the last few years there has been a revival of interest in F.H. Bradley and particularly the account of judgment contained in The Principles of Logic. Many of those who discuss Bradley’s theory of judgment mistakenly assume that it can best be seen as a linguistic account. They insist that what Bradley says can be understood as an account of the meaning and reference of words or sentences. In this paper I will argue that Bradley’s theory of judgment is (...) essentially a psychological theory. Judgment is the union of part of the content of an image or other mental particular with our immediate experience. There is no evidence for the linguisitc interpretation and its defenders cannot make sense of Bradley’s discussion of a number of technical points, particularly his criticism of the view that judgment is the synthesis of ideas, and his comments on the idea of “this.” I will also argue that Bradley’s account of judgment cannot be separated from his later metaphysics and is essentially Hegelian in character. To explain Bradley’s theory I will begin where he does, with an examination of the nature of ideas. (shrink)